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Gutta percha is primarily made from a natural rubber-like substance known as gutta, which is derived from the sap of certain trees. It is primarily composed of polyisoprene, a polymer similar to latex. The key aspect in the context of the question lies in its typical use as a root canal filling material in dentistry, where it is combined with other materials, including zinc oxide.

Zinc oxide is added to gutta percha to enhance its properties and ensure better sealing capabilities when filling the root canals. It helps achieve a more effective and durable obturation, which is critical for successful endodontic treatment. Although gutta percha itself is a significant component, zinc oxide is an important part of the formulation that is widely recognized in dental practices.

The other materials listed do not relate closely to the composition of gutta percha in dental use. Barium salts, for example, are often used as radiopaque agents but are not a primary component of gutta percha. Silicate dioxide is primarily associated with other types of dental materials, such as glass ionomer cements. Graliam prema does not correspond to any known dental material relevant to gutta percha. Thus, while gutta percha typically includes components like